Chinese scientist claims first gene-edited human babies

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Re: Chinese scientist claims first gene-edited human babies

Post by ed » Tue Jan 08, 2019 11:16 pm

Which is why the FISA Court should scare you.
Anything that "fixes" constitutional protections is evil
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Re: Chinese scientist claims first gene-edited human babies

Post by Anaxagoras » Wed Jan 23, 2019 6:08 am

Well, looks like the Chinese authorities have announced the results of their investigation.

Baby-editing doctor ‘pursued own gain’
GUANGZHOU — Chinese authorities investigating purported gene editing of babies have confirmed that Chinese researcher He Jiankui illegally researched the subject in pursuit of personal fame and gain, China’s official Xinhua News Agency has reported.

It is claimed that He, a doctor at Southern University of Science and Technology (SUSTech) in Shenzhen, Guangdong Province, modified the fertilized eggs through genome editing.

According to the Chinese media, the provincial investigative team announced the results of its preliminary investigation on Monday, concluding that He had raised funds on his own and organized a project involving researchers from outside mainland China from June 2016 to research human gene editing for reproductive purposes.

The research was conducted between March 2017 and November 2018 on eight volunteer couples in which the husbands had contracted HIV. Two women eventually conceived babies from the genome-edited eggs. One of the women gave birth to twin girls, while the other is still pregnant. An ethical review certificate needed to approve the research had been fabricated.

A source from the investigative team reportedly told Xinhua that He’s research seriously violated relevant Chinese regulations and generated adverse effects at home and abroad.

He, others involved and participant organizations will be dealt with in line with laws and regulations, the source said.

The media also reported that public security authorities will be in charge of probing the case to determine the legality of his action.

As to the twins and the pregnant woman, the Guangdong Provincial government expressed an intention to conduct medical observations and follow-up inspections on them in cooperation with a relevant organization.

In response to the investigation, SUSTech released a statement on Monday saying that the university would sever its professional ties with He.
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Re: Chinese scientist claims first gene-edited human babies

Post by Doctor X » Wed Jan 23, 2019 8:24 am

Looks like He fucked up.

Wrong country to do that. Wakefield is free to tour the U.S. spouting his nonsense.

Pays to know your audience.

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Re: Chinese scientist claims first gene-edited human babies

Post by Anaxagoras » Tue Jun 04, 2019 3:00 am

OK, so we know that the mutation that he tried to give them makes a person immune to HIV, but does it have any other effects?

2 Chinese Babies With Edited Genes May Face Higher Risk Of Premature Death
There are new concerns about the world's first genetically modified babies.

It appears that the genetic variation a Chinese scientist was trying to re-create when he edited twin girls' DNA may be more harmful than helpful to health overall, according to a study published Monday. The study, in Nature Medicine, involves the DNA of more than 400,000 people.

"This is a cautionary tale," says Rasmus Nielsen, a professor of integrative biology at the University of California, Berkeley, who led the new study.

The Chinese scientist, He Jiankui, announced last fall that he had created twin girls from an embryo whose DNA he edited in his lab using the powerful gene-editing tool CRISPR.

He said he modified a gene known as CCR5 to protect the girls from the AIDS virus. But there's also evidence the CCR5 variation has other effects, such as making people more vulnerable to the West Nile and influenza viruses.

"We know it has many different effects. The question is: Is it overall beneficial or detrimental to have this mutation?" Nielsen says. "That was not known."

So Nielsen and his colleagues analyzed more than 400,000 people whose genes and health records are stored in the UK Biobank in Britain.

Overall, the researchers found that those who had two copies of the CCR5 variation were about 21% less likely to live until the age of 76, Nielsen and his colleagues report.

"What we found is that they had significantly increased mortality," Nielsen says. "It's rather substantial. We were quite surprised the effect was this large."

The reason isn't entirely clear, but Nielsen thinks it's probably because of an increased vulnerability to the flu.

"That's a likely explanation," Nielsen says.

The findings underscore why it was premature for the Chinese scientist to do what he did, Nielsen says.

"There are many reasons not to make CRISPR babies at this stage. And one of them is fact that we can't really predict the effect of the mutations that we induce," Nielsen says.

Other scientists agree.

"This is a lesson in humility," says George Daley, the dean of the Harvard Medical School.

"Even when we think we know something about a gene, we can always be surprised and even startled, like in this case, to find out that a gene we thought was protective may actually be a problem," Daley says.

Daley notes that according to data the Chinese scientist presented last year, He apparently didn't even manage to edit the gene as intended. So it remains far from clear how the modification he did achieve will affect the girls.

"We don't even begin to understand what the impact of those deletions would be even on the original intent, which is to prevent HIV infection. So the experiment done in China was a failure — not just ethically, but scientifically," Daley says.
The mutation in question appears to be a "knockout". Essentially the deletion of 32 base pairs.

A Mutation That Resists HIV Has Other Harmful Consequences
In the 1990s, virologists in New York learned of a genetic mutation that would become one of the most famous ever discovered. They found it in a man who could not be infected with HIV. He turned out to be missing just 32 letters in a gene called CCR5, and remarkably, it was enough to make him resistant to the virus killing so many others. About 1 percent of people of European descent carry two copies of this mutation, now known as CCR5-Δ32.

In 2018, a Chinese scientist named He Jiankui made the mutation infamous when he attempted to use CRISPR to edit CCR5-Δ32 (pronounced “CCR5-delta-32”) into human embryos. He chose this mutation, he said, because the babies’ father was HIV-positive, and he wanted to make the resulting twin girls resistant to the virus. CCR5-Δ32 is also, after all, one of the most studied mutations.

He’s work immediately provoked outrage among scientists, who knew enough to know how much they did not know about the risks of altering CCR5. And now a new study suggests that CCR5-Δ32 is indeed harmful overall.

The girls’ CCR5 genes were altered, according to data He presented, but they do not exactly match the 32-letter deletion; it’s unclear whether either of them is actually resistant to HIV. Even if they were unable to get HIV, a body of research already suggested that CCR5-Δ32 made people more vulnerable to the flu and West Nile virus. A “good” mutation in the context of HIV can be “bad” in another context. No one knew, exactly, the net effect of a CCR5-Δ32 mutation.

However, the new study, by Rasmus Nielsen and Xinzhu “April” Wei of UC Berkeley, shows that people with two copies of the mutation are 21 percent more likely to die at the age of 76, with a mortality rate of 16.5 percent, compared with 13.6 percent for those who have only one or zero copies. Only recently, Nielsen told me, have genetic databases even become big enough for these effects on mortality to be apparent.

The effect of CCR5-Δ32 on mortality is ultimately subtle, but it follows from what’s already known about this gene. CCR5 usually codes for a receptor on the surface of white blood cells, and it plays a role in normal immune responses. HIV co-opts CCR5 as a way to get into white blood cells. So to block HIV is, ironically, also to eliminate a small piece of the normal immune system.

“If you think about what these people are with Δ32, they’re like human knockouts for a fairly important gene in immune response,” says Bill Paxton, a microbiologist at the University of Liverpool who helped discover the role of CCR5 in HIV. “It’s not wholly surprising you [would] read a paper like this, and the finding is there.”

After HIV researchers made CCR5-Δ32 famous, scientists in other fields got interested in the mutation, too. Flu researchers who studied it found that it predisposes people to fatal outcomes with flu. West Nile virus researchers found the same with that disease. Neurobiologists have found evidence that CCR5-Δ32 actually enhances recovery from stroke. But this process of understanding the full scope of CCR5 has been piecemeal, essentially limited by what scientists think to look for.
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Re: Chinese scientist claims first gene-edited human babies

Post by Doctor X » Tue Jun 04, 2019 6:01 am

Yeah, but they will not get the AIDS, Anax.

Why do you want CHILDREN to get the AIDS, Anax?

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Re: Chinese scientist claims first gene-edited human babies

Post by sparks » Tue Jun 04, 2019 7:10 am

Haven't they put that fucker up against the wall yet?
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Re: Chinese scientist claims first gene-edited human babies

Post by Doctor X » Tue Jun 04, 2019 7:14 am

Thought he "disappeared" or something.

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Re: Chinese scientist claims first gene-edited human babies

Post by Anaxagoras » Tue Jun 04, 2019 8:08 am

As far as I know he hasn't been seen or heard from since, unless I missed it.
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Re: Chinese scientist claims first gene-edited human babies

Post by Doctor X » Tue Jun 04, 2019 9:06 am

Wait, you are back?

Not giving back your stereo!




And my friend is still using the tentacles.




For great justice.

--J.D.
Mob of the Mean: Free beanie, cattle-prod and Charley Fan Club!
"Doctor X is just treating you the way he treats everyone--as subhuman crap too dumb to breathe in after you breathe out."--Don
DocX: FTW.--sparks
"Doctor X wins again."--Pyrrho
"Never sorry to make a racist Fucktard cry."--His Humble MagNIfIcence
"It was the criticisms of Doc X, actually, that let me see more clearly how far the hypocrisy had gone."--clarsct
"I'd leave it up to Doctor X who has been a benevolent tyrant so far."--Grammatron
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Shit. That's going to end up in your sig."--Pyrrho
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Re: Chinese scientist claims first gene-edited human babies

Post by sparks » Wed Jun 05, 2019 12:53 am

"For great justice."

BWAHA.


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Re: Chinese scientist claims first gene-edited human babies

Post by shemp » Wed Jun 05, 2019 2:33 am

sparks wrote:
Tue Jun 04, 2019 7:10 am
Haven't they put that fucker up against the wall yet?
They threw him into a cell with some ass-rapists.
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Re: Chinese scientist claims first gene-edited human babies

Post by shemp » Wed Jun 05, 2019 2:36 am

Doctor X wrote:
Tue Jun 04, 2019 6:01 am
Yeah, but they will not get the AIDS, Anax.

Why do you want CHILDREN to get the AIDS, Anax?

--J.D.
But will they get TEH AUTIZM?!?/?11?
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Re: Chinese scientist claims first gene-edited human babies

Post by Anaxagoras » Sat Jun 22, 2019 11:48 am

A Russian Biologist Wants To Create More Gene-Edited Babies
"How it can be unethical if we will make [a] healthy baby instead of diseased?" Rebrikov told NPR during his first broadcast interview. "Why? Why [is it] unethical?"
OK, tell me more.
Rebrikov wants to create babies from embryos whose DNA he would edit to protect the resulting children from HIV. Rebrikov would edit a gene called CCR5 to replicate a naturally occurring variation that protects people from HIV.

"The rationale is to guarantee that the baby will be HIV-negative — that's it," Rebrikov says.
Wait, isn't that the same exact rationale that the Chinese guy gave?
It's the same rationale given by a Chinese scientist, He Jiankui, when he created the world's first gene-edited babies. The birth of the gene-modified twin Chinese girls last year triggered an international firestorm, as well as calls for a global moratorium on creating gene-edited babies until doing so can be demonstrated to be safe and necessary.

Rebrikov says his research has shown that it's possible to make precise genetic changes in embryos using the gene-editing technique CRISPR. He claims to have verified the safety by comparing the DNA of edited embryos with the unedited DNA of the couples used to create them.

"My experiments show that, yes, it's safe. We demonstrated it's safe to use," says Rebrikov, who is also a researcher at the Pirogov Russian National Research Medical University in Moscow.
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Re: Chinese scientist claims first gene-edited human babies

Post by sparks » Sat Jun 22, 2019 11:59 am

And as soon as about 1000 competent peeps sign off on the safety of it, we'll consider it. In the meantime, more information please.

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