SARS-CoV-2 vaccines

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Pyrrho
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Re: SARS-CoV-2 vaccines

Post by Pyrrho »

A comparison of the Pfizer/BioNTech vaccine and the Moderna vaccine:

https://www.statnews.com/2020/12/19/a-s ... -vaccines/
The flash of light you saw in the sky was not a UFO. Swamp gas from a weather balloon was trapped in a thermal pocket and reflected the light from Venus.
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Pyrrho
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Re: SARS-CoV-2 vaccines

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https://www.fda.gov/news-events/press-a ... 9-vaccines
We have been following the discussions and news reports about reducing the number of doses, extending the length of time between doses, changing the dose (half-dose), or mixing and matching vaccines in order to immunize more people against COVID-19. These are all reasonable questions to consider and evaluate in clinical trials. However, at this time, suggesting changes to the FDA-authorized dosing or schedules of these vaccines is premature and not rooted solidly in the available evidence. Without appropriate data supporting such changes in vaccine administration, we run a significant risk of placing public health at risk, undermining the historic vaccination efforts to protect the population from COVID-19.

The available data continue to support the use of two specified doses of each authorized vaccine at specified intervals. For the Pfizer-BioNTech COVID-19 vaccine, the interval is 21 days between the first and second dose. And for the Moderna COVID-19 vaccine, the interval is 28 days between the first and second dose.
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Witness
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Re: SARS-CoV-2 vaccines

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Image

:pound_head:
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Pyrrho
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Re: SARS-CoV-2 vaccines

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It is reasonable to be concerned about the rapid development resulting in atypically shorter times to evaluate effects. Post-study surveillance is not turning up anything of major concern at this point. By the time most people get the vaccine it will have been several months since the conclusion of phase 3 clinical trials and more will be known.
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Anaxagoras
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Re: SARS-CoV-2 vaccines

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Pyrrho wrote: Mon Jan 04, 2021 10:05 pm A comparison of the Pfizer/BioNTech vaccine and the Moderna vaccine:

https://www.statnews.com/2020/12/19/a-s ... -vaccines/
Each dose of Pfizer’s contains 30 micrograms of vaccine. Moderna went with a much larger dose of vaccine, 100 micrograms. It means it is using a little more than three times as much vaccine per person as Pfizer is. And yet, they aren’t getting better results.
Smaller doses seem to be just as effective
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Pyrrho
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Re: SARS-CoV-2 vaccines

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The mechanism of action is likely to be different for each vaccine.
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Witness
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Re: SARS-CoV-2 vaccines

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Image
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Witness
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Re: SARS-CoV-2 vaccines

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Wealthy donors received vaccines through Florida nursing home

The invitations alarmed local officials and may have violated state and national guidelines.
https://www.washingtonpost.com/health/2 ... d-vaccine/

Ah, Florida, South America in the USA. :mrgreen:
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Witness
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Re: SARS-CoV-2 vaccines

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Moderna CEO says vaccine likely to protect for 'couple of years'

PARIS (Reuters) - Moderna’s COVID-19 mRNA vaccine is likely to offer protection of up to a couple of years, its chief executive said on Thursday, even though more data is still needed to make a definitive assessment.

The U.S. biotech company, which stunned the world last year by coming up with a vaccine against the disease caused by the new coronavirus in just a few weeks, received approval for its shot from the European Commission on Wednesday.

Given vaccines development and pharmacovigilance usually requires years, the protection duration of COVID-19 shots is a lingering question for scientists and regulators.

“The nightmare scenario that was described in the media in the spring with a vaccine only working a month or two is, I think, out of the window,” Moderna CEO Stephane Bancel said at an event organised by financial services group Oddo BHF.

“The antibody decay generated by the vaccine in humans goes down very slowly (...) We believe there will be protection potentially for a couple of years.”

Bancel added his company was about to prove that its vaccine would also be effective against variants of the coronavirus seen in Britain and South Africa.
https://www.reuters.com/article/us-heal ... SKBN29C0YK
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Pyrrho
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Re: SARS-CoV-2 vaccines

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The flash of light you saw in the sky was not a UFO. Swamp gas from a weather balloon was trapped in a thermal pocket and reflected the light from Venus.
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Witness
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Re: SARS-CoV-2 vaccines

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Norwegian Medicines Agency links 13 deaths to vaccine side effects. Those who died were frail and old

The Norwegian Medicines Agency linked 13 deaths to the corona vaccine’s side effects. Those who died had two things in common – they were old and frail.

A total of 23 deaths have been reported in connection with the corona vaccination.

So far, 13 of these have been assessed.

“The reports might indicate that common side effects from mRNA vaccines, such as fever and nausea, may have led to deaths in some frail patients,” chief physician Sigurd Hortemo in the Norwegian Medicines Agency noted.

Side effects

The Norwegian Medicines Agency and the National Institute of Public Health (FHI) jointly assess all side effects reports.

As a result, the FHI has updated the corona vaccination guide with new advice on the vaccination of frail elderly people.

“If you are very frail, you should probably not be vaccinated,” Steinar Madsen at the Norwegian Medicines Agency said at a webinar on corona vaccine for journalists on Thursday.
https://norwaytoday.info/news/norwegian ... d-old/amp/

Better to be young, rich and healthy than old, poor and sick…
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Anaxagoras
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Re: SARS-CoV-2 vaccines

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Witness wrote: Fri Jan 15, 2021 11:33 pm
Norwegian Medicines Agency links 13 deaths to vaccine side effects. Those who died were frail and old

The Norwegian Medicines Agency linked 13 deaths to the corona vaccine’s side effects. Those who died had two things in common – they were old and frail.

A total of 23 deaths have been reported in connection with the corona vaccination.

So far, 13 of these have been assessed.

“The reports might indicate that common side effects from mRNA vaccines, such as fever and nausea, may have led to deaths in some frail patients,” chief physician Sigurd Hortemo in the Norwegian Medicines Agency noted.

Side effects

The Norwegian Medicines Agency and the National Institute of Public Health (FHI) jointly assess all side effects reports.

As a result, the FHI has updated the corona vaccination guide with new advice on the vaccination of frail elderly people.

“If you are very frail, you should probably not be vaccinated,” Steinar Madsen at the Norwegian Medicines Agency said at a webinar on corona vaccine for journalists on Thursday.
https://norwaytoday.info/news/norwegian ... d-old/amp/

Better to be young, rich and healthy than old, poor and sick…
This is the first time I've heard of actual deaths caused by the vaccines.

So those who are very frail are also very likely to die if they do get the Covid. Which risk is higher?
A fool thinks himself to be wise, but a wise man knows himself to be a fool.
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Grammatron
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Re: SARS-CoV-2 vaccines

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What kind of metric is "very frail"?
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Witness
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Re: SARS-CoV-2 vaccines

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The Trump Administration Was Just Kidding When It Said It Had Tons More Vaccine Doses to Ship Out (It Has Zero)

Surprise: Team Trump has royally f---ed up the COVID-19 vaccine rollout.

Earlier this week, Health and Human Services Secretary Alex Azar announced that the federal government would start releasing COVID-19 doses that had been held in reserve for second shots, as part of an effort to ramp up a distribution process that has been plagued by chaos and delay. “This new system gives states a strong incentive to ensure that...doses are going to work protecting people rather than sitting on shelves or in freezers,” Azar said at the time. The move was applauded by many, including Ohio governor Mike DeWine, who called it a “welcome change,” with other supporters saying that despite the fact that it might result in a small delay for people’s second shots, it was more important to get as many doses out as quickly as possible as deaths from the virus hit record numbers and a new, even more contagious variant spreads through the U.S. There was just one teeny, tiny problem with the new plan, so small that the federal government apparently didn’t think to mention it at the time. It didn‘t have any more doses to ship out. Whoops! Their bad.

On Friday, The Washington Post reported the news of the colossal fuckup:
Because both of the vaccines authorized for emergency use in the United States are two-dose regimens, the Trump administration’s initial policy was to hold back second doses to protect against the possibility of manufacturing disruptions. But that approach shifted in recent weeks, according to the officials, who spoke on the condition of anonymity because they were not authorized to discuss the matter. These officials were told that Operation Warp Speed, which is overseeing the distribution of vaccines, stopped stockpiling second doses of the Pfizer-BioNTech vaccine at the end of last year. The last shots held in reserve of Moderna’s supply, meanwhile, began shipping out over the weekend.

[It] meant there was no stockpile of second doses waiting to be shipped, as Trump administration officials suggested this week. Azar, at a Tuesday briefing, said, “Because we now have a consistent pace of production, we can now ship all of the doses that had been held in physical reserve.” He explained the decision as part of the “next phase” of the nation’s vaccination campaign.
Now, local health and government officials throughout the country who had expected their exceedingly limited supply of vaccines to be doubling starting next week, and had planned to dramatically expand availability to millions of high-risk and elderly people, are learning that, no, that’s not happening. And, not surprisingly, they’re pretty pissed. On Friday, Oregon governor Kate Brown took to Twitter to express her palpable—and reasonable!—outrage, writing: “Last night, I received disturbing news, confirmed to me directly by General Perna of Operation Warp Speed: States will not be receiving increased shipments of vaccines from the national stockpile next week, because there is no federal reserve of doses. I am demanding answers from the Trump Administration. I am shocked and appalled that they have set an expectation on which they could not deliver, with such grave consequences. This is a deception on a national scale. Oregon’s seniors, teachers, all of us, were depending on the promise of Oregon’s share of the federal reserve of vaccines being released to us.”

Colorado governor Jared Polis was similarly enraged, tweeting: “I’m shocked we were lied to and there is no national reserve. Federal announcements that 2nd dose being held in reserve was going to be released led us to expect 210,000 doses next week, other Govs made similar plans now we find out we’ll only get 79,000 next week.

Of course, ask the Trump administration, and it did nothing wrong. States just misunderstood them when they claimed many more doses were on the way. Per CNN:
Oregon Health Director Patrick Allen, in a letter to Azar in which he recounted a call with Brown and Operation Warp Speed CEO General Gustave Perna on Thursday, demanded that the HHS chief reconcile his statement about “releasing the entire supply” with this revelation.

In an interview with CNN, Allen described the call as an “awkward discussion” in which Perna had confirmed there was no physical stockpile of vaccine but made it seem as if states had simply misunderstood the administration’s plans. “I do not believe I misunderstood,” Allen said. Allen confirmed that Oregon will have to delay its plan to start vaccinating seniors January 23, since no surge in vaccine is coming. “It’s just so disappointing,” he added. “People are desperate for the vaccine, and we have worked so hard to be able to expand who’s eligible, and to not be able to do it is just crushing right now.”
https://www.vanityfair.com/news/2021/01 ... s-screw-up for the rest.

Warped speed… :|