## SARS-CoV-2 vaccines

We are the Borg.
Witness
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### Re: SARS-CoV-2 vaccines

Vaccine found 92% effective in Israel, in first controlled result outside trials

Only 31 out of 163,000 fully vaccinated Maccabi members caught virus, indicating Pfizer shots living up to expectations; expert: Results ‘well within expected standard deviation’

A medical worker prepares a COVID-19 vaccine in Kiryat Ye'arim, on January 25, 2021. (Yonatan Sindel/Flash90)

Pfizer’s coronavirus vaccine is showing 92 percent effectiveness in Israel, according to the world’s first big controlled investigation on how it works outside of clinical tests.

Only 31 out of 163,000 Israelis vaccinated by Maccabi Healthcare Services were diagnosed with COVID-19 in their first 10 days of full-strength protection, its top vaccine statistics analyst, Anat Ekka Zohar, told The Times of Israel on Thursday.

Maccabi found that an equivalent sample of unvaccinated Israelis was 11 times more likely to be diagnosed with the coronavirus, which allowed it to calculate the effectiveness rate.

“This is very, very good news,” Ekka Zohar said. “It is the first study in the world that looks at such a large number of fully vaccinated patients.”

Pfizer achieved 95% efficacy in clinical trials, and doctors worldwide are looking to Israel with bated breath to see whether the vaccine comes close to that figure in real-world use.
https://www.timesofisrael.com/vaccine-f ... de-trials/
Pyrrho
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### Re: SARS-CoV-2 vaccines

https://www.npr.org/sections/coronaviru ... re-covid-1
A global study of nearly 44,000 found that the COVID-19 vaccine made by Johnson & Johnson is 66% effective in preventing moderate to severe disease.

The study was conducted in the U.S., Latin America and South Africa. The vaccine did better at preventing disease in this country – 72% percent — and less well in South Africa – 57% efficacy. The efficacy seen in Latin America was 66%.
The flash of light you saw in the sky was not a UFO. Swamp gas from a weather balloon was trapped in a thermal pocket and reflected the light from Venus.
Witness
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### Re: SARS-CoV-2 vaccines

Backlash grows for ‘selfish millionaire’ who got vaccine meant for Indigenous people

Canadian casino executive Rodney Baker and his wife were initially fined C$2,300 for breaking public health rules A millionaire Canadian couple who traveled to a remote community to receive a coronavirus vaccine intended for vulnerable and elderly Indigenous people are facing growing calls for a tougher punishment after they were initially fined C$2,300 (US$1,800) for breaking public health rules. Casino executive Rodney Baker and his wife Ekaterina Baker, an actor, travelled by chartered plane to Beaver Creek, a community of 100 in Canada’s Yukon territory, where a mobile team was administering the Moderna vaccine to locals, including elderly members of the White River First Nation. At the mobile clinic, the Bakers posed as local motel employees to receive the vaccine, officials allege. They were detained at the airport in Whitehorse, the territorial capital, as they traveled home to Vancouver, British Columbia. The couple were fined for violating Yukon’s Civil Emergency Measures Act, but local community leaders argue that the fine will mean little to the wealthy couple. https://www.theguardian.com/world/2021/ ... ns-scandal NJ hospital gave vaccine to wealthy donors, ineligible relatives in December RARITAN TOWNSHIP — Weeks before the state began opening eligibility to the general public, a hospital in Hunterdon County was handing out the coveted COVID-19 vaccine to deep-pocketed donors and the relatives of its executives. And while vulnerable senior citizens wondered when it would be their turn, recipients of the vaccine at Hunterdon Medical Center included officials' young-adult children who were able to get the shot at a time when only front-line healthcare workers and long-term care residents could. The line-cutting at the hospital was revealed by vaccine registry information that a whistleblower provided to New Jersey 101.5, demonstrating that despite the state's plan for an "equitable" distribution of the vaccine, those with privilege are managing to get it anyway. More than a month after a connected few with ties to Hunterdon Medical Center, Hunterdon Healthcare and the Hunterdon Healthcare Foundation received their vaccines, fewer than 630,000 people have been vaccinated in a state with more than 6.3 million adults. About 5% of the recipients in New Jersey have been Latino and just 3% have been Black. Just under a third of the supply has gone to those over 65, the most vulnerable population. https://nj1015.com/hunterdon-medica-cen ... 9-vaccine/ 'Paramedic of the Year' in Florida arrested for alleged role in theft of Covid-19 vaccines Joshua Colon, a paramedic for the Polk County Fire Rescue, faces charges for his alleged role in helping a supervisor steal doses of the Moderna vaccine. A Florida man who was named 2020 paramedic of the year admitted to investigators that he played a role in the alleged theft of coronavirus vaccine doses, the Polk County Sheriff said on Tuesday. Joshua Colon, 31, was arrested on Monday and faces forgery, fraud and misconduct charges after he admitted to forging paperwork to cover up what he said was a supervisor's theft of three pre-filled syringes of the Moderna Covid-19 vaccine. In a press conference, Polk County Sheriff Grady Judd said that authorities noticed there were "discrepancies" and "total confusion" on three different vaccine forms filled out by Colon, who had been given three full vials of the vaccine on Jan. 6 to administer to Polk County first responders. Authorities contacted several of the names of vaccine recipients on the forms and found that they were former firefighters who said they had never received any doses. Judd said that the 2020 Paramedic of the Year later "confessed" and began to cooperate with investigators, admitting to using false names for "fraudulent" and "wrong" reasons. Colon said he did so at the behest of his supervisor, Polk County Fire Rescue Captain Anthony Damiano. https://www.nbcnews.com/news/us-news/pa ... s-n1255701 Witness Posts: 33876 Joined: Thu Sep 19, 2013 5:50 pm ### Re: SARS-CoV-2 vaccines Covid vaccines are slowing spread of virus already, early study shows Vaccination is already easing Britain’s Covid epidemic with early data showing it is definitely reducing cases. Research due to be published within days will provide real-world evidence that Britons are being protected, including suggestions that the effect is still building a month after one dose, said Anthony Harnden, deputy chairman of the Joint Committee on Vaccination and Immunisation (JCVI). With fears about an EU export ban on vaccines, Professor Harnden said plans were in place for people to be able to mix and match vaccines if second doses of the Pfizer jab were unavailable. Decisions on vaccinating teachers and other key workers in the second phase are likely to involve political and economic input because clear evidence that the vaccines block transmission of the virus is unlikely to be available for months, he said. https://www.thetimes.co.uk/article/covi ... lbwwgsvrh/ Witness Posts: 33876 Joined: Thu Sep 19, 2013 5:50 pm ### Re: SARS-CoV-2 vaccines The vaccine news continues to be better than many people realize. The news about the vaccines continues to be excellent — and the public discussion of it continues to be more negative than the facts warrant. Here’s the key fact: All five vaccines with public results have eliminated Covid-19 deaths. They have also drastically reduced hospitalizations. “They’re all good trial results,” Caitlin Rivers, an epidemiologist at Johns Hopkins University, told me. “It’s great news.” Many people are instead focusing on relatively minor differences among the vaccine results and wrongly assuming that those differences mean that some vaccines won’t prevent serious illnesses. It’s still too early to be sure, because a few of the vaccine makers have released only a small amount of data. But the available data is very encouraging — including about the vaccines’ effect on the virus’s variants. ... [...] all five of the vaccines — from Pfizer, Moderna, AstraZeneca, Novavax and Johnson & Johnson — look extremely good. Of the roughly 75,000 people who have received one of the five in a research trial, not a single person has died from Covid, and only a few people appear to have been hospitalized. None have remained hospitalized 28 days after receiving a shot. To put that in perspective, it helps to think about what Covid has done so far to a representative group of 75,000 American adults: It has killed roughly 150 of them and sent several hundred more to the hospital. The vaccines reduce those numbers to zero and nearly zero, based on the research trials. Zero isn’t even the most relevant benchmark. A typical U.S. flu season kills between five and 15 out of every 75,000 adults and hospitalizes more than 100 of them. https://www.nytimes.com/2021/02/01/brie ... olice.html Witness Posts: 33876 Joined: Thu Sep 19, 2013 5:50 pm ### Re: SARS-CoV-2 vaccines Russia's Sputnik V vaccine is 91.6% effective against symptomatic Covid-19, interim trial results suggest After criticism last year for an early rollout, Russia's Sputnik V vaccine is 91.6% effective against symptomatic Covid-19 and 100% effective against severe and moderate disease, according to an interim analysis of the vaccine's Phase 3 trial results. The preliminary findings were published in The Lancet on Tuesday and are based on data gathered from 19,866 participants, of which around three-quarters (14,964) received two doses of the vaccine and a quarter (4,902) were given a placebo. Sixteen cases of symptomatic Covid-19 were confirmed in the vaccine group 21 days after participants received the first vaccine dose. Sixty two cases were found in the placebo group -- equating to an efficacy of 91.6%. The trial included 2,144 people over the age of 60 and a sub-analysis conducted on this group revealed the vaccine was well tolerated and had a similar efficacy of 91.8%. The team also analyzed the efficacy of the vaccine against severe and moderate Covid-19 disease and 21 days after the first dose no severe or moderate cases were reported in the vaccinated group, while 20 were reported in the placebo group. Serious adverse events were also rare and none was considered to be associated with vaccination. The majority of side-effects that were reported were mild, such as pain at the injection site, flu like symptoms and low energy levels, according to the study. The analysis includes only symptomatic cases of Covid-19, however, and the authors note more research is needed to understand the vaccine's efficacy against asymptomatic Covid-19, transmission and how long protection may last. https://edition.cnn.com/2021/02/02/heal ... index.html Anaxagoras Posts: 29081 Joined: Wed Mar 19, 2008 5:45 am Location: Yokohama/Tokyo, Japan ### Re: SARS-CoV-2 vaccines An interesting read: Myths of Vaccine Manufacturing A fool thinks himself to be wise, but a wise man knows himself to be a fool. William Shakespeare Rob Lister Posts: 23398 Joined: Sun Jul 18, 2004 7:15 pm Title: Incipient toppler Location: Swimming in Lake Ed ### Re: SARS-CoV-2 vaccines Anaxagoras wrote: Wed Feb 03, 2021 12:32 pm An interesting read: Myths of Vaccine Manufacturing Derek rocks. Witness Posts: 33876 Joined: Thu Sep 19, 2013 5:50 pm ### Re: SARS-CoV-2 vaccines Pfizer says its Covid-19 vaccine will bring in$15 billion this year.

The drug maker Pfizer expects its Covid-19 vaccine to generate $15 billion in revenue this year, executives said Tuesday on a call with investors to discuss the company’s fourth-quarter earnings in 2020. Pfizer and other companies have struggled to keep up with the demand for their vaccines, as the United States and countries around the world are scrambling to vaccinate as many people as possible to combat the spread of more contagious variants. In comments to investors on Tuesday, the company’s chief executive, Dr. Albert Bourla, said Pfizer had delivered 29 million doses to the United States by the end of January, and 65 million doses worldwide, and that it expected to manufacture up to 2 billion doses by the end of the year. It shares profits with BioNTech, the German company that developed the vaccine. Dr. Bourla also said Pfizer now expects to deliver the 200 million doses, for about$4 billion, that it had promised to the United States two months ahead of time, by May instead of July. That accelerated timeline can be attributed in large part to Pfizer now counting six doses in every vial of vaccine that it ships instead of five — after health care providers learned they could extract an additional dose using special syringes.

“We foresee no issues with delivering the commitments we have made,” Dr. Bourla said.

And, in an indication that the coronavirus may be here to stay, Dr. Bourla said he expects the vaccine to become a standard part of its business, given the likely need for booster shots to address waning immunity to the virus as well as variants that could reduce its effectiveness.

Pfizer has said that preliminary tests of its vaccine against more contagious variants have shown that it continues to be effective, but suggested that a third shot of the same vaccine may be needed, and the company has also not ruled out changing its vaccine to address the new variants. Moderna, which has developed a similar vaccine, has said it is already working on an adapted booster shot.
https://www.nytimes.com/live/2021/02/02 ... us-vaccine
sparks
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### Re: SARS-CoV-2 vaccines

The world is dying yet, business as usual.

Why am I not surprised?
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Anaxagoras
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### Re: SARS-CoV-2 vaccines

Bill Gates' annual letter, if anyone's interested:

https://www.gatesnotes.com/2021-Annual- ... tIQAvD_BwE

He has a short video too.

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Anaxagoras
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### Re: SARS-CoV-2 vaccines

Oxford coronavirus vaccine shows sustained protection of 76% during the 3-month interval until the second dose
Analyses reveal single standard dose efficacy from day 22 to day 90 post vaccination of 76% with protection not falling in this three-month period
So, this is referring to just one single dose of the AZ vaccine.

The UK is taking an approach of delaying the second dose until 12 weeks after the first one, I believe, so as to allow more people to get that first dose faster. I guess 12 weeks would be 84 days technically, but they are counting up to 90 days.
After the second dose vaccine efficacy from two standard doses is 82.4% with the 3-month interval being used in the UK. (82.4% effective, with a 95% confidence interval of 62.7% - 91.7% at 12+ weeks)
Data supports the 4-12 week prime-boost dosing interval recommended by many global regulators
Analyses of PCR positive swabs in UK population suggests vaccine may have substantial effect on transmission of the virus with 67% reduction in positive swabs among those vaccinated
Researchers at the University of Oxford have today published in Preprints with The Lancet an analysis of further data from the ongoing trials of the vaccine. In this, they reveal that the vaccine efficacy is higher at longer prime-boost intervals, and that a single dose of the vaccine is 76% effective from 22- to up to 90-days post vaccination.
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Witness
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### Re: SARS-CoV-2 vaccines

Not a vaccine, but interesting if it works as advertised:
Israeli hospital says it may have found Covid-19 cure as all treated patients make full recovery

A number of severely ill Covid-19 patients made a full recovery within five days after being treated with a relatively unknown cancer drug, according to multiple media reports in Israel today.

Researchers at the Ichilov Hospital in Tel Aviv told Israeli’s KAN News network that out of 30 seriously ill Covid-patients that were treated with the drug, 29 showed a significant improvement within two days and all were released within three to five days.

One patient ultimately did recover but this took “a few days” longer, according to the hospital’s Covid-19 lead, professor Nadir Arber.

The medication, called EXO-CD24, is a targeted drug that was reportedly developed as a cure for certain types of cancer.

Ichilov hospital decided to administer the drug to 30 moderate-to-seriously ill Covid-19 patients, which led to a success rate of 96% within a set trial period of five days, explained Arber, who is part of the hospital’s Integrated Cancer Prevention Centre.

EXO-CD24 is relatively inexpensive and must be given once a day for a period of five days. It fights the cytokine storm, a potentially lethal immune overreaction as a result of a coronavirus infection, which is believed to be responsible for many Covid-related deaths.

The drug uses so-called ‘exosomes’ – tiny carrier pouches that shuttle materials between cells – to deliver a protein called CD24 to the lungs, which Arber has been studying for decades.

“This protein is located on the surface of cells and has a well-known and important role in regulating the immune system,” researcher Shiran Shapira, who is part of Arber’s research team, told the Times of Israel earlier today.

Israeli media hail the results as “a huge breakthrough” and the hospital has reportedly reached out to the country’s Ministry of Health, requesting them for permission to extend and expand the trial.
https://www.cityam.com/israeli-hospital ... -recovery/
Anaxagoras
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### Re: SARS-CoV-2 vaccines

That's interesting
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The Atheist
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### Re: SARS-CoV-2 vaccines

However, it appears to be ineffective against the SA variant, where they've suspended its use: https://www.washingtonpost.com/world/eu ... story.html
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Anaxagoras
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### Re: SARS-CoV-2 vaccines

I wonder if we're going to need a new vaccine.

I assume that Pfizer and Moderna are already working on another one (or more).
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Anaxagoras
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### Re: SARS-CoV-2 vaccines

Israel Won’t Reach Covid-19 Immunity Even If All Adults Jabbed

Apparently the vaccine has not been tested for children, so its use has only been approved for adults.

Not entirely sure why that would be the case, since lots of other vaccines are given to children. Maybe the thinking is that because children are at lower risk from the disease, they needn't be vaccinated? But then, they could still be vectors.
Israel is unlikely to reach herd immunity from Covid-19 even if all adults are inoculated, because there is currently no vaccine that has been approved for children, Israel’s top public health official said on Sunday.

“The moment we have 2.5 million children that can’t be vaccinated, we probably won’t reach herd immunity, even if the entire population that can be vaccinated, will be vaccinated,” Sharon Alroy-Preis said at a parliamentary committee meeting.

More than a third of the 9.3 million people who live in Israel have had at least one dose of the Pfizer Inc.-BioNTech SE vaccine, and about one-fifth are fully vaccinated.
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robinson
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### Re: SARS-CoV-2 vaccines

Even if the children were vaccinated, there will be another strain

It will never be over
still working on Sophrosyne, but I will no doubt end up with Hubris
Pyrrho
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### Re: SARS-CoV-2 vaccines

Just waiting my turn for infection here, Boss.
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The Atheist
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### Re: SARS-CoV-2 vaccines

Anaxagoras wrote: Tue Feb 09, 2021 2:17 am Apparently the vaccine has not been tested for children, so its use has only been approved for adults.
I don't get that, either.

We know mutations are happening, and they will continue to happen while there are infections.

Plus, all the data I've seen regarding the UK and SA strains say they're more likely to infect children and youth.
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Witness
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### Re: SARS-CoV-2 vaccines

Common asthma drug cuts COVID-19 hospitalization risk, recovery time - Oxford study

A commonly used asthma treatment appears to reduce the need for hospitalizations as well as recovery time for COVID-19 patients if given within seven days of symptoms appearing, researchers at the University of Oxford said on Tuesday.

The findings were made following a mid-stage study of the steroid budesonide, sold as Pulmicort by AstraZeneca Plc and also used for treating smoker’s lung.

The 28-day study of 146 patients suggested that inhaled budesonide reduced the risk of urgent care or hospitalization by 90% when compared with usual care, Oxford University said.

Researchers said the trial was inspired by the fact that patients with chronic respiratory disease, who are often prescribed inhaled steroids, were significantly under-represented among hospitalized COVID-19 patients during early days of the pandemic.

Initial data from the study also found volunteers treated with budesonide had a quicker resolution of fever and fewer persistent symptoms.
https://www.reuters.com/article/us-heal ... SKBN2A92DA
The Atheist
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### Re: SARS-CoV-2 vaccines

Witness wrote: Wed Feb 10, 2021 1:25 amResearchers said the trial was inspired by the fact that patients with chronic respiratory disease, who are often prescribed inhaled steroids, were significantly under-represented among hospitalized COVID-19 patients during early days of the pandemic.
This kind of thing is entirely due to a disgraceful lack of co-ordination.

I was way back in Wuhan that doctors on the ground saw fewer smokers and ex-smokers, and fewer asthma patients than they expected.

And it's taken 12 months to figure out why.

Still, more very good news on the treatment front - there's a bit of an array of steroids that appear to be working, and the good news about them is that unlike anti-virals, they don't affect the virus at all, so mutations won't matter.
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Witness
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### Re: SARS-CoV-2 vaccines

The Atheist wrote: Fri Feb 12, 2021 12:44 am the good news about them is that unlike anti-virals, they don't affect the virus at all, so mutations won't matter.
Good point. Could also be useful for the next, similar, virus.

Pfizer vaccine found to give strong immune response to new Covid variants

Study finds patients have strong T-cell response after one jab, and second boosts antibody response

People who have received two doses of the Pfizer vaccine have been found to have strong T-cell responses against the Kent and South African variants of Covid, suggesting that the vaccine will continue to protect against serious disease in the coming months.

In the first study to test immune responses against the variants circulating in populations, researchers found that although antibody responses against the new variants were blunted, they may still be high enough to protect most people from becoming infected, after a second dose of vaccine has been given.

Although previous studies had suggested that antibodies from those vaccinated with the Pfizer/BioNTech jab could recognise and neutralise viruses carrying some of the individual mutations found in the South African and Kent variants – albeit at slightly lower levels compared with previous variants – these were tested on engineered viruses rather than ones isolated from real patients.

These studies also did not look at T cells, which annihilate virus-infected cells and support the production of antibodies. Both immune responses help provide lasting protection after vaccination, but antibody responses are easier to measure.

William James, a professor of virology at the University of Oxford, and his colleagues took blood samples from people who had recovered from Covid-19, and health workers who had received either one or two doses of the Pfizer/BioNTech vaccine. They also obtained isolates of the B117 and B1.351 virus variants first identified in Kent and South Africa, and of an older variant similar to those circulating a year ago. Antibodies and T cells from the individuals were then tested against these viruses to see how well they performed.

The study, which has not yet been reviewed by other scientists, found that people’s antibodies were moderately effective against the original virus after their first dose of vaccine, less effective against the Kent variant, and were unable to neutralise the South African variant.

However, they had strong T-cell responses against all known variants after the first jab. “It may not necessarily protect you against infection, but it’s very likely that this first dose will make it much easier for your immune system to make a good response the next time around,” said James. “We think this is why that second dose produces such a good strong antibody response, because the T cells are already there, ready to react.”
https://www.theguardian.com/world/2021/ ... d-variants
Anaxagoras
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### Re: SARS-CoV-2 vaccines

The first people are being vaccinated in Japan. Seeing it live on TV.

They are starting with doctors and nurses of course.

Still, they are taking things very slowly. It seems that they are limiting the first group to 40,000 in what amounts to a kind of clinical trial, and mass vaccinations won't begin in earnest until April:

Japan to start administering COVID-19 vaccine to health workers
Japan is set to begin administering a COVID-19 vaccine on Wednesday to an initial group of 40,000 health workers, before expanding to cover the elderly and people with preexisting conditions.
Of the initial group, 20,000 will participate in a study to track side effects potentially caused by the vaccine developed by U.S. drugmaker Pfizer Inc. and Germany's BioNTech SE and the frequency with which they occur.

They will be asked to keep daily records for seven weeks after taking the first of two shots. The shots will be administered three weeks apart.
A further 3.7 million front-line health workers are to begin being inoculated in March, followed by 36 million people aged 65 or older from April.

People with preexisting conditions such as diabetes or heart disease and those working at elderly care facilities will come next, and then finally the general population.
So it appears that the rate of vaccinations will be very slow for the rest of this month and next month at least. They want to do their own study of the side effects
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Witness
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### Re: SARS-CoV-2 vaccines

Pyrrho
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### Re: SARS-CoV-2 vaccines

The flash of light you saw in the sky was not a UFO. Swamp gas from a weather balloon was trapped in a thermal pocket and reflected the light from Venus.
Anaxagoras
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### Re: SARS-CoV-2 vaccines

https://www.bloomberg.com/graphics/covi ... tribution/
The biggest vaccination campaign in history is underway. More than 271 million doses have been administered across 108 countries, according to data collected by Bloomberg. The latest rate was roughly 6.36 million doses a day.

In the U.S., more Americans have now received at least one dose than have tested positive for the virus since the pandemic began. So far, 80.5 million doses have been given. In the last week, an average of 2.01 million doses per day were administered.
Vaccines Across America
Across the U.S., 24.3 doses have been administered for every 100 people, and 75% of the shots delivered to states have been administered.
The Path to Immunity in the U.S.
In the U.S., the latest vaccination rate is 2,010,790 doses per day, on average. At this rate, it will take an estimated 6 months to cover 75% of the population with a two-dose vaccine.
So they've managed to reach 2 million doses per day, which seems pretty good. Hopefully they can push it even higher than that.
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Witness
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### Re: SARS-CoV-2 vaccines

Catholics in New Orleans and St Louis told to avoid Johnson & Johnson vaccine

Religious leaders in two cities say use of abortion-derived cells in development means believers should prefer Pfizer and Moderna
https://www.theguardian.com/world/2021/ ... on-vaccine
Pyrrho
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### Re: SARS-CoV-2 vaccines

More for us then.
The flash of light you saw in the sky was not a UFO. Swamp gas from a weather balloon was trapped in a thermal pocket and reflected the light from Venus.